The rationality of anti-missile equipment configuration is an important index to measure the effectiveness of anti-missile combat. Since there are few studies on the rationality evaluation of anti-missile equipment configuration， and effective means and unified standards are insufficient， the main factors affecting the rationality evaluation of anti-missile equipment configuration are analyzed by reviewing the research status. According to the configuration requirements of actual combat scenarios， an evaluation index system is established to evaluate the rationality of anti-missile equipment configuration based on the configuration area and multi-attribute decision making， and the rationality evaluation is refined according to different application scenarios. Finally， a typical application scenario is taken as an example to verify and analyze the constructed index system， which provides a certain reference for the actual deployment and configuration of anti-missile equipment.